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Back to Cancer

Milk Products and Colorectal Cancer

According to the Third Expert Report by the World Cancer Research Fund and the American Institute for Cancer Research,  the world’s leading authority on cancer prevention research related to diet, weight and physical activity, there is strong evidence (probable) that consuming dairy products (total dairy, milk, cheese) reduces the risk of colorectal cancer.

Highlights

  • The effect of dairy products in reducing colorectal cancer risk is likely mediated, at least in part, by calcium.
  • Several other components in milk products that could also be responsible for this protective effect, include vitamin D, conjugated linoleic acid (CLA), butyric acid (short-chain fatty acid), lactoferrin, lactic acid bacteria and sphingolipids.

Basic Facts on Colorectal Cancer

There are many known risk factors for colorectal cancer including the following, among others:1

  • Family history of colorectal cancer;
  • Being overweight or obese;
  • Not being physically active;
  • Alcohol;
  • Smoking;
  • Eating processed meat;
  • Eating a diet low in fibre;
  • Inflammatory bowel disease

About 26,800 Canadians were diagnosed with colorectal cancer in 2017.1 It is the second most commonly diagnosed cancer in Canada (excluding non-melanoma skin cancers).

The Evidence

According to the Third Expert Report published in 2018 by the World Cancer Research Fund and the American Institute for Cancer Research, there is strong evidence that dairy products (total dairy, milk, cheese) are associated with decreased risk of colorectal cancer.2

Potential Mechanisms

There are several potential mechanisms by which dairy products may reduce the risk of colorectal cancer involving several dairy components.

Calcium
Calcium may protect against colorectal cancer, with evidence for several plausible mechanisms.1

In a dose-response meta-analysis of prospective observational studies, it was concluded that both dietary and supplementary calcium may continue to decrease colorectal cancer risk beyond 1,000 mg.3

Several biological mechanisms may explain the protective effect of calcium against colorectal cancer.2, 3, 4 Calcium may:

  • Suppress proliferation, promote terminal cell differentiation and induce apoptosis of colorectal tumour cells;
  • Bind secondary bile acids (bile acids which are formed from the action of intestinal bacteria on bile acids synthesized by the liver) or ionized fatty acids so as to inhibit their ability to modify colonic cells;
  • Reduce colonic K-ras gene mutations.

Vitamin D
The evidence that vitamin D or foods containing it protect against colorectal cancer is limited but generally consistent.There are plausible mechanisms for growth-restraining, anticancer effects of vitamin D on colon cells.5 As well, the effects of vitamin D and calcium are interrelated because both restrain cell proliferation and induce differentiation and apoptosis of intestinal cells.2 Other potential mechanisms relate to improved immune function, reduced inflammation, inhibition of angiogenesis and regulation of microRNA expression with higher vitamin D status.2 Furthermore, calcium-mediated effects are dependent on vitamin D levels.

Conjugated linoleic acid (CLA)
The anticancer effects of CLA have been demonstrated in numerous animal models. CLA has been shown to modulate eicosanoids production, reduce the synthesis of prostaglandins, interfere with cell signalling pathways, inhibit DNA synthesis, modify the fluidity of cell membranes, promote apoptosis, and modulate angiogenesis.6, 7

Evidence from human studies is limited; however, it does suggest that CLA may help protect against colorectal cancer. A study using data from the Swedish Mammography Cohort has demonstrated an inverse relationship between high-fat milk products and CLA and colorectal cancer.8

Other dairy components
Butyric acid is another dairy fatty acid that has been suggested to play a beneficial role against colorectal cancer. It has been shown to inhibit proliferation and induce differentiation in tumour cell lines.7 

In animal models, lactoferrin, a milk protein, has been shown to suppress carcinogenesis in the colon and other organs. Additionally, lactoferrin may inhibit the growth of adenomatous polyps in humans.9 

Lactic acid bacteria found in fermented dairy products may also protect the epithelium surface of the colon. They may bind to the apical surface of colonic cells and suppress the excretion of toxins from putrefactive bacteria, thus protecting the epithelium surface.7, 10

Sphingolipids in milk fat are also a potent inhibitor of cell growth and may induce differentiation and apoptosis.10

Conclusion

According to the World Cancer Research Fund International, the authority on diet and cancer, there is strong evidence that milk products (total dairy, milk, cheese) reduce the risk of developing colorectal cancer.

Several components in milk products that could be responsible for this protective effect include: calcium, vitamin D, lactoferrin and butyric acid.

Further research is needed to fully elucidate all the potential mechanisms by which milk products may help protect against colorectal cancer.

References

  1. Canadian Cancer Society. 2018. Colorectal cancer. Available at www.cancer.ca  Accessed September 27, 2018.
  2. World Cancer Research Fund / American Institute for Cancer Research. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective, Continuous Update Project Expert Report 2018 . Available at dietandcancerreport.org  Accessed September 27, 2018.
  3. Keum N et al. Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies. Int J Cancer 2014;135:1940-1948.
  4. Murphy N et al. Consumption of dairy products and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). PLoS One 2013;8:e72715.
  5. Lamprecht SA and Lipkin M. Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanismsNat Rev Cancer 2003;3:601-614.
  6. Dilzer A and Park Y. Implication of conjugated linoleic acid (CLA) in human health. Crit Rev Food Sci Nutr 2012;52:488-513.
  7. Norat T and Riboli E. Dairy products and colorectal cancer: a review of possible mechanisms and epidemiological evidence. Eur J Clin Nutr 2003;57:1-17.
  8. Larsson SC et al. High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography CohortAm J Clin Nutr 2005;82:894-900.
  9. Tsuda H et al. Cancer prevention by bovine lactoferrin: from animal studies to human trial. Biometals 2010;23:399-409.
  10. Pufulete M. Intake of dairy products and risk of colorectal neoplasia. Nutr Res Rev 2008;21:56-67.

Keywords: colon cancer , cancer prevention , milk , calcium , vitamin d , conjugated linoleic acid , lactoferrin , lactic acid bacteria


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