Back to Bone Health and Osteoporosis
Milk Products and Bone Health: Potential Mechanisms
A review of potential mechanisms for calcium and vitamin D in bone health are outlined as follows: 1
1) Offsetting obligatory losses
- Calcium and vitamin D are both needed in order to offset obligatory losses of calcium from the human skeleton. Vitamin D is necessary for efficient absorption of calcium from the diet.
2) Reducing excessive bone remodelling (turnover)
- Both calcium and vitamin D, particularly together, reduce excessive bone remodelling or turnover;
- Bone remodelling doubles across menopause and triples by the age of 65 years;
- Several lines of evidence show that high remodelling rates increase bone fragility;
- Both increased calcium intake and increased vitamin D status reduce bone remodeling because they reduce parathyroid hormone secretion.
3) Antifracture efficacy
- Although antifracture efficacy has been well documented for calcium, the efficacy of vitamin D alone has been less well studied;
- Some studies have now shown that vitamin D supplementation alone can reduce osteoporotic fractures while other studies showed no change; however, some methodological differences appear to exist;
- There was a higher vitamin D level achieved in the study, which did show a benefit compared to the other studies;
- The serum 25(OH) vitamin D value, and not the oral dose used, is important with respect to various measured outcomes.
4) Vitamin D and neuromuscular function
- Vitamin D has also been shown to improve lower-extremity neuromuscular function and to reduce fall frequency.
References
- Heaney RP. Bone health. Am J Clin Nutr 2007; 85(suppl):300S-303S.
Keywords: health studies, bone health
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